eCysticFibrosis Review
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VOLUME 5 - ISSUE 14
PODCAST LINK BELOW

Agents for the management of Pseudomonas aeruginosa infection
Our guest author is Shawn Aaron, MD from the University of Ottawa, in Ottawa, Ontario.

After participating in this activity, the participant will demonstrate the ability to:

Discuss optimal therapy of chronic Pseudomonas aeruginosa infection in patients with cystic fibrosis.
Describe the pathophysiology of pulmonary exacerbations associated with Pseudomonas infection in patients with cystic fibrosis.
Evaluate the optimal choice of antibiotics to treat Pseudomonas-associated pulmonary exacerbations in patients with cystic fibrosis.

This discussion, offered as a downloadable audio file and companion transcript, covers the important issues related to the effects of CFTR modification targets in the format of case-study scenarios for the clinical practice. This program is a follow up to Volume 5, Issue 13 eCysticFibrosis Review Newsletter - Agents for the management of Pseudomonas aeruginosa infection

The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.
Shawn Aaron, MD Shawn Aaron, MD
Senior Scientist, Clinical Epidemiology Program
Ottawa Hospital Research Institute
Professor
Division Director, Respirology
University of Ottawa
Ottawa, Ontario, Canada


Guest Faculty Disclosure
Dr. Aaron has disclosed that he has no relationships with a commercial entity.

Unlabeled/Unapproved Uses
Dr. Aaron will include references to the off-label or unapproved uses of drug or products, including inhaled colistin, inhaled levofloxacin, inhaled ciprofloxacin, liposomal amikacin, doripenem, and sitafloxacin.


Release Date
November 19, 2015
Expiration Date
November 18, 2017
Michael P. Boyle, MD, FCCP
Professor of Medicine
Director, Adult Cystic Fibrosis Program
Johns Hopkins University
Baltimore, MD
Peter J. Mogayzel, Jr., MD, PhD
Professor of Pediatrics
Director, Cystic Fibrosis Center
Johns Hopkins University
Baltimore, MD
Donna W. Peeler, RN, BSN
Clinical Coordinator
Cystic Fibrosis Center
Johns Hopkins University
Baltimore, MD
Meghan Ramsay, MS, CRNP
Clinical Coordinator
Adult Clinical Coordinator
Cystic Fibrosis Center
Johns Hopkins University
Baltimore, MD
  IMPORTANT CME/CE INFORMATION
Program Begins Below
accreditation statements
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Johns Hopkins University School of Medicine and the Institute for Johns Hopkins Nursing. The Johns Hopkins University School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

The Institute for Johns Hopkins Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.

The Institute for Johns Hopkins Nursing and the American Nurses Credentialing Center do not endorse the use of any commercial products discussed or displayed in conjunction with this educational activity.

credit designations
Physicians
Podcast: The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses
Podcast: This 0.5 contact hour Educational Activity is provided by the Institute for Johns Hopkins Nursing.

Respiratory Therapists
For United States: Visit this page to confirm that your state will accept the CE Credits gained through this program.

For Canada: Visit this page to confirm that your province will accept the CE Credits gained through this program.

intended audience
This activity has been developed for pulmonologists, pediatric pulmonologists, gastroenterologists, pediatricians, infectious disease specialists, respiratory therapists, dieticians, nutritionists, nurses, and physical therapists.

There are no fees or prerequisites for this activity.

The estimated time to complete this activity is 30 minutes.

launch date
This program launched on November 12, 2014 and is published monthly; activities expire two years from the date of publication.

disclaimer statement
The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.

Statement of Need
Based on a review of the current literature, including national and regional measures, detailed conversations with expert educators at Johns Hopkins, and a survey of potential program participants, this program will address the following core patient care gaps:
Disease-Modifying Therapies
Clinicians need guidance in understanding how new findings describing CFTR-modifying therapies may improve their treatment of patients with cystic fibrosis.
Incomplete clinician awareness of genotype/phenotype correlations in non-pulmonary targets of CFTR-modifying therapies may limit their ability to provide optimal patient care.
Nutrition
Clinicians lack effective guidance to increase caloric intake in patients who are nutritionally compromised.
Clinicians do not fully understand how to manage the complexities of pancreatic enzyme replacement therapy to achieve optimal results in their patients.
Pseudomonas aeruginosa
Clinicians have unanswered questions about P. aeruginosa eradication in asymptomatic patients with positive cultures.
New data and new choices for selecting initial inhaled anti-pseudomonal agents have created confusion.
Conflicting data about pulmonary exacerbations has led to incorrect clinical assumptions and inappropriate treatment regimens.

planner disclosure
As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of the Johns Hopkins University School of Medicine Office of Continuing Medical Education (OCME)
to require signed disclosure of the existence of financial relationships with industry from any individual in a position to control the content of a CME activity sponsored by OCME.

Members of the Planning Committee are required to disclose all relationships regardless of their relevance to the content of the activity. Faculty are required to disclose only those relationships that are relevant to their specific presentation. The following relationships have been reported for this activity:





Michael P. Boyle, MD, FCCP, discloses that he has served on scientific advisory boards for Gilead Sciences, Inc, Genentech, Vertex Pharmaceuticals Incorporated, and Savara.

No other planners have indicated that they have any financial interests or relationships with a commercial entity.

Guest Author's Disclosures

This activity is supported by educational grants from AbbVie, Gilead Sciences, Inc, and Vertex Pharmaceuticals Incorporated.

SUCCESSFUL COMPLETION
To successfully complete this activity, participants must read the content, and visit the Johns Hopkins University School of Medicine's CME website and the Institute for Johns Hopkins Nursing . If you have already registered for other Hopkins CE programs at these sites, simply enter the requested information when prompted. Otherwise, complete the registration form to begin the testing process. A passing grade of 70% or higher on the post-test/evaluation is required to receive CE credit.

statement of responsibility
The Johns Hopkins University School of Medicine takes responsibility for the content, quality and scientific integrity of this CME activity.

CONFIDENTIALITY DISCLAIMER FOR CME CONFERENCE ATTENDEES
I certify that I am attending a Johns Hopkins University School of Medicine CME activity for accredited training and/or educational purposes.

I understand that while I am attending in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the "Privacy Regulations"). Protected health information is information about a person's health or treatment that identifies the person.

I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential. I agree not to post or discuss this protected health information, including pictures and/or videos, on any social media site (e.g. Facebook, Twitter, etc.), in any electronic messaging program or through any portable electronic device.

I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is: Johns Hopkins Privacy Officer, telephone: 410-735-6509, HIPAA@jhmi.edu

"The Office of Continuing Medical Education at the Johns Hopkins University School of Medicine, as provider of this activity, has relayed information with the CME attendees/participants and certifies that the visitor is attending for training, education and/or observation purposes only."

For CME Questions, please contact the CME Office (410) 955-2959 or e-mail cmenet@jhmi.edu. For CME Certificates, please call (410) 502-9634.

Johns Hopkins University School of Medicine Office of Continuing Medical Education Turner 20/720 Rutland Avenue Baltimore, Maryland 21205-2195

Reviewed & Approved by: General Counsel, Johns Hopkins Medicine (4/1/03)
(Updated 4/09 and 3/14).

internet cme/ce policy
The Office of Continuing Medical Education (CME) at the Johns Hopkins University School of Medicine is committed to protecting the privacy of its members and customers. The Johns Hopkins University SOM CME maintains its Internet site as an information resource and service for physicians, other health professionals and the public.

Continuing Medical Education at the Johns Hopkins University School of Medicine will keep your personal and credit information confidential when you participate in a CME Internet-based program. Your information will never be given to anyone outside the Johns Hopkins University School of Medicine's CME program. CME collects only the information necessary to provide you with the services that you request.

To participate in additional CME activities presented by the Johns Hopkins University School of Medicine Continuing Medical Education Office, please visit www.hopkinscme.edu

Hardware & Software Requirements
To access activities, users will need:
• A computer with an internet connection
• An HTML5 compliant web browser or Internet Explorer 8 (and higher)


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COMPLETE THE
POST-TEST


Step 1. Click on the appropriate link below. This will take you to the post-test.

Step 2. If you have participated in a Johns Hopkins on-line course, login. Otherwise, please register.

Step 3. Complete the post-test and course evaluation.

Step 4. Print out your certificate.
Respiratory Therapists
Visit this page to confirm that your state will accept the CE Credits gained through this program or click on the link below to go directly to the post-test.
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